Assemblathon 2 participation
Last Updated on Monday, 10 October 2011 16:26 Monday, 10 October 2011 15:59
CoBiG² is participating in the Assemblathon 2, along with other 19 groups from Canada, China, France, Italy, Russia, the UK, and the USA.
CoBiG² presentation in the CBA
Last Updated on Friday, 05 February 2010 17:21 Friday, 05 February 2010 17:01
The Computational Biology and Population Genomics Group: a general framework and a case study
Octávio S. Paulo
Assistant Professor DBA/FCUL; Head of Group CBA
In the first part of the talk the research aims of the group will be presented, as well as its current members, projects and courses. The second part will focus on a case study that has been investigated by several members of the group.
This group’s objective is to apply Genetics/Genomics and Computational Biology to the study of selection, adaptation and speciation, a more specific goal being that of developing a better understanding of how the environment affects the population genetics of wild organisms. This aim is achieved by the joint use of neutral and selected molecular markers, as well as through the study of the association of the genotype with the environment. Understanding the genetics and genomics of the environmental change and its consequences for biodiversity and its preservation is the overall aim of this research group.
In close interaction with the above work and goals, third-party and in-house developed software, bioinformatics pipelines and data mining computational techniques are used to analyze the generated population-genetic, phylogenetic, and phylogeographic datasets. A more recent challenge in this direction is the analysis of the large datasets that we are about to generate using next-generation sequencing technology under a population genomics and gene discovery framework, to address the scientific questions above.
In the second part of the talk, a general overview will be given on the evolutionary history of the Ocellated lizards, as a show case of the approaches that the group is applyingt. The study of this group of species started in the 80s and a considerable amount of data is already available, namely on mtDNA, nuclear sequences, STRs and AFLPs. An integrative perspective of the data will be given under a more general framework of the Western Mediterranean biogeography.